Pesquisa | BVS Violência e Saúde

1.

Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy.

Perez-Ramirez, Cesar A; Nakano, Haruko; Law, Richard C; Matulionis, Nedas; Thompson, Jennifer; Pfeiffer, Andrew; Park, Junyoung O; Nakano, Atsushi; Christofk, Heather R.

Cell ; 187(1): 204-215.e14, 2024 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-38070508

2.

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan, William J; Mullen, Peter J; Schmid, Ernst W; Flores, Aimee; Momcilovic, Milica; Sharpley, Mark S; Jelinek, David; Whiteley, Andrew E; Maxwell, Matthew B; Wilde, Blake R; Banerjee, Utpal; Coller, Hilary A; Shackelford, David B; Braas, Daniel; Ayer, Donald E; de Aguiar Vallim, Thomas Q; Lowry, William E; Christofk, Heather R.

Cell ; 175(1): 117-132.e21, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30197082

3.

The metabolic milieu of metastases.

Sullivan, William J; Christofk, Heather R.

Cell ; 160(3): 363-4, 2015 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-25635452

4.

O-Mg! Lactate Drives Mg²⁺ Mobilization.

Wilde, Blake R; Christofk, Heather R.

Mol Cell ; 80(5): 762-763, 2020 12 03.

Artigo em Inglês | MEDLINE | ID: mdl-33275887

5.

Nutrient regulation of development and cell fate decisions.

Tu, William B; Christofk, Heather R; Plath, Kathrin.

Development ; 150(20)2023 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-37260407

6.

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Gu, Yuchao; Albuquerque, Claudio P; Braas, Daniel; Zhang, Wei; Villa, Genaro R; Bi, Junfeng; Ikegami, Shiro; Masui, Kenta; Gini, Beatrice; Yang, Huijun; Gahman, Timothy C; Shiau, Andrew K; Cloughesy, Timothy F; Christofk, Heather R; Zhou, Huilin; Guan, Kun-Liang; Mischel, Paul S.

Mol Cell ; 67(1): 128-138.e7, 2017 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-28648777

7.

Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome.

Zhang, Sicheng; Williams, Kevin J; Verlande-Ferrero, Amandine; Chan, Alvin P; Su, Gino B; Kershaw, Erin E; Cox, James E; Maschek, John Alan; Shapira, Suzanne N; Christofk, Heather R; de Aguiar Vallim, Thomas Q; Masri, Selma; Villanueva, Claudio J.

J Lipid Res ; 65(2): 100434, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-37640283

8.

Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.

Bonglack, Emmanuela N; Messinger, Joshua E; Cable, Jana M; Ch'ng, James; Parnell, K Mark; Reinoso-Vizcaíno, Nicolás M; Barry, Ashley P; Russell, Veronica S; Dave, Sandeep S; Christofk, Heather R; Luftig, Micah A.

Proc Natl Acad Sci U S A ; 118(25)2021 06 22.

Artigo em Inglês | MEDLINE | ID: mdl-34161263

9.

Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing.

Lu, Eric; Hatchell, Kathryn E; Nielsen, Sarah M; Esplin, Edward D; Ouyang, Karen; Nykamp, Keith; Zavoshi, Shirin; Li, Shantao; Zhang, Liying; Wilde, Blake R; Christofk, Heather R; Boutros, Paul C; Shuch, Brian.

Cancer ; 128(4): 675-684, 2022 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-34724198

10.

Histone acetylation regulates intracellular pH.

McBrian, Matthew A; Behbahan, Iman Saramipoor; Ferrari, Roberto; Su, Trent; Huang, Ta-Wei; Li, Kunwu; Hong, Candice S; Christofk, Heather R; Vogelauer, Maria; Seligson, David B; Kurdistani, Siavash K.

Mol Cell ; 49(2): 310-21, 2013 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-23201122

11.

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

Chin, Randall M; Fu, Xudong; Pai, Melody Y; Vergnes, Laurent; Hwang, Heejun; Deng, Gang; Diep, Simon; Lomenick, Brett; Meli, Vijaykumar S; Monsalve, Gabriela C; Hu, Eileen; Whelan, Stephen A; Wang, Jennifer X; Jung, Gwanghyun; Solis, Gregory M; Fazlollahi, Farbod; Kaweeteerawat, Chitrada; Quach, Austin; Nili, Mahta; Krall, Abby S; Godwin, Hilary A; Chang, Helena R; Faull, Kym F; Guo, Feng; Jiang, Meisheng; Trauger, Sunia A; Saghatelian, Alan; Braas, Daniel; Christofk, Heather R; Clarke, Catherine F; Teitell, Michael A; Petrascheck, Michael; Reue, Karen; Jung, Michael E; Frand, Alison R; Huang, Jing.

Nature ; 510(7505): 397-401, 2014 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-24828042

12.

Viral hijacking of cellular metabolism.

Thaker, Shivani K; Ch'ng, James; Christofk, Heather R.

BMC Biol ; 17(1): 59, 2019 07 18.

Artigo em Inglês | MEDLINE | ID: mdl-31319842

13.

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.

Graham, Nicholas A; Minasyan, Aspram; Lomova, Anastasia; Cass, Ashley; Balanis, Nikolas G; Friedman, Michael; Chan, Shawna; Zhao, Sophie; Delgado, Adrian; Go, James; Beck, Lillie; Hurtz, Christian; Ng, Carina; Qiao, Rong; Ten Hoeve, Johanna; Palaskas, Nicolaos; Wu, Hong; Müschen, Markus; Multani, Asha S; Port, Elisa; Larson, Steven M; Schultz, Nikolaus; Braas, Daniel; Christofk, Heather R; Mellinghoff, Ingo K; Graeber, Thomas G.

Mol Syst Biol ; 13(2): 914, 2017 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-28202506

14.

Cell cycle: Division enzyme regulates metabolism.

Krall, Abigail S; Christofk, Heather R.

Nature ; 546(7658): 357-358, 2017 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-28607481

15.

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.

Domigan, Courtney K; Warren, Carmen M; Antanesian, Vaspour; Happel, Katharina; Ziyad, Safiyyah; Lee, Sunyoung; Krall, Abigail; Duan, Lewei; Torres-Collado, Antoni X; Castellani, Lawrence W; Elashoff, David; Christofk, Heather R; van der Bliek, Alexander M; Potente, Michael; Iruela-Arispe, M Luisa.

J Cell Sci ; 128(12): 2236-48, 2015 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-25956888

16.

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.

Drew, Brian G; Hamidi, Habib; Zhou, Zhenqi; Villanueva, Claudio J; Krum, Susan A; Calkin, Anna C; Parks, Brian W; Ribas, Vicent; Kalajian, Nareg Y; Phun, Jennifer; Daraei, Pedram; Christofk, Heather R; Hewitt, Sylvia C; Korach, Kenneth S; Tontonoz, Peter; Lusis, Aldons J; Slamon, Dennis J; Hurvitz, Sara A; Hevener, Andrea L.

J Biol Chem ; 290(9): 5566-81, 2015 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-25468909

17.

New aspects of the Warburg effect in cancer cell biology.

Bensinger, Steven J; Christofk, Heather R.

Semin Cell Dev Biol ; 23(4): 352-61, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22406683

18.

Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition.

Smith, Kathleen B; Tran, Linh M; Tam, Brenna M; Shurell, Elizabeth M; Li, Yunfeng; Braas, Daniel; Tap, William D; Christofk, Heather R; Dry, Sarah M; Eilber, Fritz C; Wu, Hong.

Am J Pathol ; 182(4): 1400-11, 2013 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-23416162

19.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin D; Malstrom, Scott; Khan, Tahsin M; Kung, Charles; Skoumbourdis, Amanda P; Veith, Henrike; Southall, Noel; Walsh, Martin J; Brimacombe, Kyle R; Leister, William; Lunt, Sophia Y; Johnson, Zachary R; Yen, Katharine E; Kunii, Kaiko; Davidson, Shawn M; Christofk, Heather R; Austin, Christopher P; Inglese, James; Harris, Marian H; Asara, John M; Stephanopoulos, Gregory; Salituro, Francesco G; Jin, Shengfang; Dang, Lenny; Auld, Douglas S; Park, Hee-Won; Cantley, Lewis C; Thomas, Craig J; Vander Heiden, Matthew G.

Nat Chem Biol ; 8(10): 839-47, 2012 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-22922757

20.

Cancer: A metabolic metamorphosis.